GW 627368

Ligand id: 1953

Name: GW 627368

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 110.39
Molecular weight 544.17
XLogP 5.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Wilson RJ, Giblin GM, Roomans S, Rhodes SA, Cartwright KA, Shield VJ, Brown J, Wise A, Chowdhury J, Pritchard S et al.. (2006)
GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist.
Br. J. Pharmacol., 148 (3): 326-39. [PMID:16604093]
2. Wilson RJ, Giles H. (2005)
Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes.
Br. J. Pharmacol., 144 (3): 405-15. [PMID:15655509]