quinpirole

Ligand id: 2

Name: quinpirole

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 31.92
Molecular weight 219.17
XLogP 2.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
D3 receptor Rn Agonist Full agonist 7.3 – 7.8 pKi - 1,10
pKi 7.3 – 7.8 [1,10]
D4 receptor Hs Agonist Full agonist 7.5 pKi - 4,7,11
pKi 7.5 [4,7,11]
D3 receptor Hs Agonist Full agonist 6.4 – 8.0 pKi - 1,3,5,7-11
pKi 6.4 – 8.0 (Ki 3.98x10-7 – 1x10-8 M) [1,3,5,7-11]
D2 receptor Hs Agonist Full agonist 4.9 – 7.7 pKi - 1,3,7,9-11
pKi 4.9 – 7.7 [1,3,7,9-11]
5-HT1A receptor Hs Agonist Full agonist 5.8 pKi - 6
pKi 5.8 [6]
5-HT2B receptor Hs Agonist Full agonist 5.0 – 6.5 pKi - 2,4
pKi 5.0 – 6.5 [2,4]
5-HT2A receptor Hs Agonist Full agonist 5.0 – 5.5 pKi - 2,4
pKi 5.0 – 5.5 [2,4]
5-HT2C receptor Hs Agonist Full agonist 5.0 – 5.5 pKi - 2,4
pKi 5.0 – 5.5 [2,4]
D2 receptor Rn Agonist Full agonist 5.2 pKi - 10
pKi 5.2 [10]