substance P

Ligand id: 2098

Name: substance P

Abbreviated name: SP

Species: Human, Mouse, Rat

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View more information in the IUPHAR Pharmacology Education Project: substance p

Structure and Physico-chemical Properties

2D Structure
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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
NK1 receptor
NK2 receptor
NK3 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
NK1 receptor Hs Agonist Full agonist 8.5 – 10.3 pKi - 1-2
pKi 8.5 – 10.3 [1-2]
NK2 receptor Hs Agonist Full agonist 5.9 – 6.9 pKi - 1,3,7
pKi 5.9 – 6.9 [1,3,7]
NK3 receptor Hs Agonist Full agonist 5.0 – 6.0 pKi - 6-7
pKi 5.0 – 6.0 [6-7]
NK3 receptor Mm Agonist Full agonist 5.3 pKi - 6
pKi 5.3 [6]
MRGPRX2 Hs Agonist Agonist 6.0 pEC50 - 4-5
pEC50 6.0 (EC50 1.071x10-6 M) [4-5]
Description: In a calcium mobilisation asay.
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields