[Ala11,22,28]VIP

Ligand id: 2278

Name: [Ala11,22,28]VIP

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC1 receptor Hs Agonist Agonist 8.1 pKi - 2
pKi 8.1 (Ki 7.4x10-9 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Hs Agonist Agonist 5.6 pKi - 2
pKi 5.6 (Ki 2.352x10-6 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Agonist 7.6 – 10.2 pEC50 - 1-2
pEC50 10.2 (EC50 5.7x10-11 M) [1]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
pEC50 9.4 (EC50 4x10-10 M) [2]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 7.6 (EC50 2.56x10-8 M) [1]
Description: calcium influx in CHO cells stably expressing recombinant receptor
VPAC2 receptor Hs Agonist Agonist 5.0 – 5.9 pEC50 - 1-2
pEC50 5.9 (EC50 1.222x10-6 M) [2]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 <5.0 (EC50 >1x10-5 M) [1]
Description: calcium influx in CHO cells stably expressing recombinant receptor
pEC50 <5.0 (EC50 >1x10-5 M) [1]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
PAC1 receptor Hs Agonist Agonist 5.0 – 5.8 pEC50 - 1
pEC50 5.8 (EC50 1.582x10-6 M) [1]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
pEC50 <5.0 (EC50 >1x10-5 M) [1]
Description: calcium influx in CHO cells stably expressing recombinant receptor