diazoxide   Click here for help

GtoPdb Ligand ID: 2409

Synonyms: Proglycem® | SCH-6783 | SRG-95213
Approved drug PDB Ligand
diazoxide is an approved drug (FDA (1973))
Compound class: Synthetic organic
Comment: Diazoxide is a potassium channel activator.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 66.91
Molecular weight 229.99
XLogP 1.94
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)S(=O)(=O)N=C(N2)C
Isomeric SMILES Clc1ccc2c(c1)S(=O)(=O)N=C(N2)C
InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
Bioactivity Comments
Note that we have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir6.1 Mm Activator Agonist - - 2x10-4 3
Conc range: 2x10-4 M [3]
Voltage: -60.0 mV
Kir6.2 Rn Activator Agonist - - 2x10-4 2
Conc range: 2x10-4 M [2]
Voltage: -60.0 mV
Kir6.2 Mm Activator Agonist 4.2 pEC50 - 1
pEC50 4.2 (EC50 6.3x10-5 M) [1]
Voltage: Physiological