Ligand id: 2409

Name: diazoxide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 66.91
Molecular weight 229.99
XLogP 1.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Note that we have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir6.1 Mm Activator Agonist - - 2x10-4 3
Conc range: 2x10-4 M [3]
Voltage: -60.0 mV
Kir6.2 Rn Activator Agonist - - 2x10-4 2
Conc range: 2x10-4 M [2]
Voltage: -60.0 mV
Kir6.2 Mm Activator Agonist 4.2 pEC50 - 1
pEC50 4.2 (EC50 6.3x10-5 M) [1]
Voltage: Physiological