diazoxide   Click here for help

GtoPdb Ligand ID: 2409

Synonyms: Proglycem® | SCH-6783 | SRG-95213
Approved drug PDB Ligand
diazoxide is an approved drug (FDA (1973))
Compound class: Synthetic organic
Comment: Diazoxide is a potassium channel activator.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 66.91
Molecular weight 229.99
XLogP 1.94
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)S(=O)(=O)N=C(N2)C
Isomeric SMILES Clc1ccc2c(c1)S(=O)(=O)N=C(N2)C
InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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Summary of Clinical Use Click here for help
Diazoxide acts as a peripheral vasodilator and is used to reduce blood pressure.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Diazoxide activates potassium channels which in turn switches off voltage-gated calcium ion channels, This inhibits calcium flux across the sarcolemma leading to failure of the contractile response and hence causes local smooth muscle relaxation.