nicorandil   Click here for help

GtoPdb Ligand ID: 2411

Synonyms: Ikorel® | SG-75
Approved drug
nicorandil is an approved drug (UK (2009))
Compound class: Synthetic organic
Comment: Nicorandil is an antianginal medication that acts as an adenosine triphosphate (ATP)-sensitive K+ (K(ATP)) channel opener and a nitrate [1].
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nicorandil

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 94.36
Molecular weight 211.06
XLogP 0.42
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES [O-][N+](=O)OCCNC(=O)c1cccnc1
Isomeric SMILES [O-][N+](=O)OCCNC(=O)c1cccnc1
InChI InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir6.1 Mm Activator Agonist - - 3x10-4 2
Conc range: 3x10-4 M [2]
Voltage: -60.0 – 60.0 mV
Kir6.2 Hs Activator - - - -