nicorandil   Click here for help

GtoPdb Ligand ID: 2411

Synonyms: Ikorel® | SG-75
Approved drug
nicorandil is an approved drug (UK (2009))
Compound class: Synthetic organic
Comment: Nicorandil is an antianginal medication that acts as an adenosine triphosphate (ATP)-sensitive K+ (K(ATP)) channel opener and a nitrate [1].
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nicorandil

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 94.36
Molecular weight 211.06
XLogP 0.42
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES [O-][N+](=O)OCCNC(=O)c1cccnc1
Isomeric SMILES [O-][N+](=O)OCCNC(=O)c1cccnc1
InChI InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
No information available.
Summary of Clinical Use Click here for help
Nicorandil is not approeved by the US FDA or EMA. Individual national approval agencies have authorised marketing of this drug. Nicorandil is used to treat chronic stable angina pectoris.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Nicorandil has dual properties, acting as a nitrate and as a K+ATP channel agonist. At low plasma concentrations the nitrate action dilates the large coronary arteries, and at high plasma concentrations nicorandil induces K+ATP channel opening which reduces coronary vascular resistance [1]. These actions combine to provide cardioprotective effects.
External links Click here for help