SDZ 205557   Click here for help

GtoPdb Ligand ID: 258

Synonyms: SDZ-205557
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 64.79
Molecular weight 300.12
XLogP 2.38
No. Lipinski's rules broken 0
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Canonical SMILES CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC
Isomeric SMILES CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC
InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT4 receptor Mm Antagonist Antagonist 8.1 pKi - 2
pKi 8.1 [2]
5-HT4 receptor Rn Antagonist Antagonist 7.6 – 7.7 pKi - 1
pKi 7.6 – 7.7 [1]