SDZ 205557   Click here for help

GtoPdb Ligand ID: 258

Synonyms: SDZ-205557
Compound class: Synthetic organic
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 64.79
Molecular weight 300.12
XLogP 2.38
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC
Isomeric SMILES CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC
InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
1. Bonhaus DW, Berger J, Adham N, Branchek TA, Hsu SA, Loury DN, Leung E, Wong EH, Clark RD, Eglen RM. (1997)
[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.
Neuropharmacology, 36 (4-5): 671-9. [PMID:9225293]
2. Watts SW, Gilbert L, Webb RC. (1995)
5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats.
Hypertension, 26 (6 Pt 2): 1056-9. [PMID:7498967]