coenzyme A

Ligand id: 3044

Name: coenzyme A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 22
Hydrogen bond donors 9
Rotatable bonds 20
Topological polar surface area 414.79
Molecular weight 767.12
XLogP -5.83
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
acetyl-CoA acetyltransferase 1 2.3.1.9 2acetyl CoA = acetoacetyl CoA + coenzyme A 1
hydroxymethylglutaryl-CoA synthase 2 2.3.3.10 Acetyl CoA + H2O + acetoacetyl CoA -> (S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A
ceramide synthase 1 2.3.1.24 acylCoA + sphinganine -> dihydroceramide + coenzyme A
sphingosine + acylCoA -> ceramide + coenzyme A
acetyl-CoA acetyltransferase 2 2.3.1.9 2acetyl CoA = acetoacetyl CoA + coenzyme A
ceramide synthase 4 2.3.1.24 acylCoA + sphinganine -> dihydroceramide + coenzyme A
sphingosine + acylCoA -> ceramide + coenzyme A
serine palmitoyltransferase long chain base subunit 1 2.3.1.50 L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
hydroxymethylglutaryl-CoA synthase 1 2.3.3.10 Acetyl CoA + H2O + acetoacetyl CoA -> (S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A
ceramide synthase 5 2.3.1.24 acylCoA + sphinganine -> dihydroceramide + coenzyme A
sphingosine + acylCoA -> ceramide + coenzyme A
choline O-acetyltransferase 2.3.1.6 Acetyl CoA + choline = acetylcholine + coenzyme A
ceramide synthase 2 2.3.1.24 acylCoA + sphinganine -> dihydroceramide + coenzyme A
sphingosine + acylCoA -> ceramide + coenzyme A
ceramide synthase 6 2.3.1.24 acylCoA + sphinganine -> dihydroceramide + coenzyme A
sphingosine + acylCoA -> ceramide + coenzyme A
serine palmitoyltransferase long chain base subunit 2 2.3.1.50 L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
serine palmitoyltransferase long chain base subunit 3 2.3.1.50 L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
ceramide synthase 3 2.3.1.24 acylCoA + sphinganine -> dihydroceramide + coenzyme A
sphingosine + acylCoA -> ceramide + coenzyme A
hydroxymethylglutaryl-CoA reductase 1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + NADPH -> (R)-mevalonate + coenzyme A + NADP+
Ligand mentioned in the following text fields
Eicosanoid turnover overview
SLC27 family of fatty acid transporters comments
SLC33 acetylCoA transporter comments