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zaragozic acid A   Click here for help

GtoPdb Ligand ID: 3057

Synonyms: L 694599 | L-694599 | squalestatin | squalestatin 1 | squalestatin S1
PDB Ligand
Compound class: Natural product
Comment: Zaragozic acid A is produced by fungi such as Sporormiella intermedia. It has been produced synthetically [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 14
Hydrogen bond donors 5
Rotatable bonds 19
Topological polar surface area 223.42
Molecular weight 690.29
XLogP 4.26
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

SMILES / InChI / InChIKey
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Canonical SMILES CCC(CC(C=CC(=O)OC1C(O)C2(OC1(C(=O)O)C(O)(C(=O)O)C(O2)C(=O)O)CCC(=C)C(C(Cc1ccccc1)C)OC(=O)C)C)C
Isomeric SMILES CC[C@@H](C[C@@H](/C=C/C(=O)O[C@@H]1[C@@H](O)[C@@]2(O[C@@]1(C(=O)O)[C@](O)(C(=O)O)[C@H](O2)C(=O)O)CCC(=C)[C@H]([C@@H](Cc1ccccc1)C)OC(=O)C)C)C
InChI InChI=1S/C35H46O14/c1-7-19(2)17-20(3)13-14-25(37)47-28-27(38)33(48-29(30(39)40)34(45,31(41)42)35(28,49-33)32(43)44)16-15-21(4)26(46-23(6)36)22(5)18-24-11-9-8-10-12-24/h8-14,19-20,22,26-29,38,45H,4,7,15-18H2,1-3,5-6H3,(H,39,40)(H,41,42)(H,43,44)/b14-13+/t19-,20+,22+,26+,27+,28+,29+,33-,34+,35-/m0/s1
InChI Key DFKDOZMCHOGOBR-NCSQYGPNSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

Bioactivity Comments
Zaragozic acid A inhibits the enzyme squalene synthase that is crucial for cholesterol biosynthesis.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
squalene synthase Rn Inhibitor Inhibition 10.1 pKi - 1
pKi 10.1 (Ki 7.8x10-11 M) [1]
Description: Compound was tested for inhibition of squalene synthase in rat liver.
Conditions: Concentration of substrates: 0.2-10µM FPP, 10mM NADPH. pH 7.5, 30°C
squalene synthase Hs Inhibitor Inhibition 9.6 pKi - 3
pKi 9.6 (Ki 2.5x10-10 M) [3]
Description: Human enzyme expressed in yeast, in vitro assay
Conditions: pH 7.4, 37°C
squalene synthase Hs Inhibitor Inhibition 9.1 pIC50 - 4
pIC50 9.1 (7x10-10 M) [4]
Description: in vitro, soluable microsomal enzymes purified from rat and human liver microsomes
Conditions: Concentration of FPP: 20µM