M65   Click here for help

GtoPdb Ligand ID: 3305

Synonyms: des-(Gln25-Gln41)-maxadilan | maxadilan Δ25-41
Compound class: Peptide or derivative
Comment: The properties of this maxadilan analogue were first described in [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
PAC1 receptor Hs Antagonist Antagonist 6.6 – 6.8 pIC50 - 1
⤷ pIC50 6.8 (IC50 1.496x10-7 M) [1]
Description: inhibition of cyclic AMP formation stimulated by 0.1nM PACAP-27 in CHO cells stably expressing recombinant receptor
pIC50 6.6 (IC50 2.774x10-7 M) [1]
Description: inhibition of calcium influx stimulated by 30nM PACAP-27 in CHO cells stably expressing recombinant receptor
Ligand mentioned in the following text fields
VIP and PACAP receptors overview