R3(BΔ23-27)R/I5 chimeric peptide   Click here for help

GtoPdb Ligand ID: 3907

Comment: Synthetic chimeric peptide consisting of the A chain of human INSL5 linked via cysteine bonds to a synthetic analogue of the human relaxin 3 B chain. The two subunit components are linked by disulphide bonds between cysteine residues. The sequence of the relaxin 3 component is shown via the link in the structure tab; for the sequence of the other subunit see INSL5 (A chain).
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
RXFP3 Hs Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 [1]
RXFP3 Hs Antagonist Antagonist 8.9 – 9.0 pEC50 - 2
pEC50 8.9 – 9.0 [2]
RXFP3 Rn Agonist Partial agonist 10.1 pIC50 - 3
pIC50 10.1 [3]
RXFP3 Hs Agonist Partial agonist 9.4 pIC50 - 3
pIC50 9.4 [3]
RXFP3 Rn Antagonist Antagonist 9.2 pIC50 - 3
pIC50 9.2 [3]
RXFP3 Hs Antagonist Antagonist 8.1 – 9.2 pIC50 - 3-4
pIC50 9.2 (IC50 6.7x10-10 M) [4]
pIC50 8.1 [3]
RXFP4 Hs Antagonist Antagonist 8.0 – 8.6 pIC50 - 1,4
pIC50 8.0 – 8.6 [1,4]