galangin

Ligand id: 410

Name: galangin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 90.9
Molecular weight 270.05
XLogP 3.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
A1 receptor Rn Antagonist Antagonist 6.1 pKi - 1
pKi 6.1 [1]
A2A receptor Hs Antagonist Antagonist 6.0 pKi - 1
pKi 6.0 [1]
A3 receptor Hs Antagonist Antagonist 5.5 pKi - 1
pKi 5.5 [1]
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPC5 Hs Channel blocker - 6.3 pKi - 2
pKi 6.3 (Ki 4.5x10-7 M) [2]
Description: Inhibition of lanthanide-evoked calcium entry in HEK 293 cells overexpressing hTRPC5, by patch-clamp recording.