nomifensine   Click here for help

GtoPdb Ligand ID: 4792

Synonyms: Alival® | Merital®
Approved drug
nomifensine is an approved drug (FDA (approval date not specified, withdrawn 1992))
Compound class: Synthetic organic
Comment: Nomifensine is a norepinephrine-dopamine reuptake inhibitor. Bioactivity is reported to lie with the (S) isomer.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 29.26
Molecular weight 238.15
XLogP 2.29
No. Lipinski's rules broken 0
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Canonical SMILES CN1CC(c2ccccc2)c2c(C1)c(N)ccc2
Isomeric SMILES CN1CC(c2ccccc2)c2c(C1)c(N)ccc2
InChI InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3
Selectivity at transporters
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
NET Primary target of this compound Hs Inhibitor Inhibition 8.1 pKi -
pKi 8.1 (Ki 7.94x10-9 M)
DAT Primary target of this compound Hs Inhibitor Inhibition - - -