nomifensine   Click here for help

GtoPdb Ligand ID: 4792

Synonyms: Alival® | Merital®
Approved drug
nomifensine is an approved drug (FDA (approval date not specified, withdrawn 1992))
Compound class: Synthetic organic
Comment: Nomifensine is a norepinephrine-dopamine reuptake inhibitor. Bioactivity is reported to lie with the (S) isomer.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 29.26
Molecular weight 238.15
XLogP 2.29
No. Lipinski's rules broken 0
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Canonical SMILES CN1CC(c2ccccc2)c2c(C1)c(N)ccc2
Isomeric SMILES CN1CC(c2ccccc2)c2c(C1)c(N)ccc2
InChI InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3
No information available.
Summary of Clinical Use Click here for help
Investigated as an antidepressant and in the treatment of adult ADHD. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibitor of the noradrenaline and dopamine uptake transporters.