mazindol   Click here for help

GtoPdb Ligand ID: 4797

Synonyms: Mazanor® | Sanorex®
Approved drug
mazindol is an approved drug (FDA (1973))
Compound class: Synthetic organic
Comment: Mazindol is a tetracyclic chemical, with anorectic, appetite suppressing action. Pharmacologically it acts as a sympathomimetic amine (like amphetamine).
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 35.83
Molecular weight 284.07
XLogP 3.77
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES Clc1ccc(cc1)C1(O)c2ccccc2C2=NCCN12
Isomeric SMILES Clc1ccc(cc1)C1(O)c2ccccc2C2=NCCN12
InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
NET Hs Inhibitor Inhibition 8.9 pKi -
pKi 8.9 (Ki 1.26x10-9 M)
DAT Primary target of this compound Hs Inhibitor Inhibition 8.0 pKi -
pKi 8.0 (Ki 1x10-8 M)