mazindol   Click here for help

GtoPdb Ligand ID: 4797

Synonyms: Mazanor® | Sanorex®
Approved drug
mazindol is an approved drug (FDA (1973))
Compound class: Synthetic organic
Comment: Mazindol is a tetracyclic chemical, with anorectic, appetite suppressing action. Pharmacologically it acts as a sympathomimetic amine (like amphetamine).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 35.83
Molecular weight 284.07
XLogP 3.77
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc(cc1)C1(O)c2ccccc2C2=NCCN12
Isomeric SMILES Clc1ccc(cc1)C1(O)c2ccccc2C2=NCCN12
InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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Summary of Clinical Use Click here for help
Used in the short term treatment of exogenous obesity.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The exact mechanism of action of mazindol as an obesity treatment is unknown; however, it is believed to inhibit the reuptake of noradrenaline.