dipyridamole

Ligand id: 4807

Name: dipyridamole

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View more information in the IUPHAR Pharmacology Education Project: dipyridamole, dipyridamole

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 145.44
Molecular weight 504.32
XLogP 1.76
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphodiesterase 7B Hs Inhibitor Inhibition 5.7 – 6.0 pIC50 - 3,6
pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [3,6]
phosphodiesterase 8A Hs Inhibitor Inhibition 5.1 pIC50 - 2
pIC50 5.1 (IC50 7.94x10-6 M) [2]
phosphodiesterase 8B Hs Inhibitor Inhibition 4.3 pIC50 - 5
pIC50 4.3 (IC50 5.01x10-5 M) [5]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Equilibrative nucleoside transporter 1 Hs Inhibitor Inhibition 8.8 pKi - 4
pKi 8.8 (Ki 1.5x10-9 M) [4]
Plasma membrane monoamine transporter Hs Inhibitor Inhibition 5.9 pKi - 8
pKi 5.9 [8]
Targets where the ligand is described in the comment field
Target Comment
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