TGFβ1

Ligand id: 5060

Name: TGFβ1

Species: Human

Bioactivity Comments
TGFβ is a primary driver in fibrosis (in primary fibrotic disease and desmoplastic tumours), and plays a significant part in tumour growth (including immunosuppression, epithelial-to-mesenchymal transition, angiogenesis, and metastasis).
Natural/Endogenous Targets
Target
Transforming growth factor β receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Transforming growth factor β receptor Hs Agonist Agonist - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
fresolimumab Hs Antibody Binding - - - 3
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