rizatriptan

Ligand id: 51

Name: rizatriptan

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 49.74
Molecular weight 269.16
XLogP 1.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT1D receptor Hs Agonist Full agonist 7.9 pKi - 1
pKi 7.9 [1]
5-HT1B receptor Hs Agonist Partial agonist 6.9 pKi - 1
pKi 6.9 [1]
5-ht1e receptor Hs Agonist Full agonist 6.8 pKi - 1
pKi 6.8 [1]
5-HT1F receptor Hs Agonist Full agonist 6.4 – 6.8 pKi - 1-2
pKi 6.4 – 6.8 [1-2]
5-HT1A receptor Hs Agonist Full agonist 6.4 pKi - 1
pKi 6.4 [1]