GSK690693

Ligand id: 5196

Name: GSK690693

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 137.14
Molecular weight 425.22
XLogP 1.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
GSK-690693 inhibits other AGC family kinases due to their shared ATP domain structure (eg MSK1, ROCK1, and RSK, and to a lesser extent PKA, PrkX, and PKC isozymes) [2]. CAMK family kinases AMPK and DAPK3 and STE family kinases PAK4, 5, and 6 are also inhibited by GSK-690693 [2]. See Table 5 in Heerding et al (2008) [2] for IC50s for all kinases screened for GSK-690693 inhibition.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AKT serine/threonine kinase 1 Hs Inhibitor Inhibition 8.7 pKd - 1
pKd 8.7 (Kd 2.2x10-9 M) [1]
protein kinase, cAMP-dependent, catalytic, beta subunit Hs Inhibitor Inhibition 7.9 pKd - 1
pKd 7.9 (Kd 1.3x10-8 M) [1]
protein kinase, cAMP-dependent, catalytic, alpha subunit Hs Inhibitor Inhibition 7.7 pKd - 1
pKd 7.7 (Kd 1.9x10-8 M) [1]
AKT serine/threonine kinase 1 Hs Inhibitor Inhibition 8.7 pIC50 - 2
pIC50 8.7 (IC50 2x10-9 M) [2]
protein kinase C theta Hs Inhibitor Inhibition 8.7 pIC50 - 2
pIC50 8.7 (IC50 2x10-9 M) [2]
protein kinase X-linked Hs Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 5x10-9 M) [2]
p21 (RAC1) activated kinase 6 Hs Inhibitor Inhibition 8.2 pIC50 - 2
pIC50 8.2 (IC50 6x10-9 M) [2]
Description: Data from binding assays.
AKT serine/threonine kinase 3 Hs Inhibitor Inhibition 8.1 pIC50 - 2
pIC50 8.1 (IC50 9x10-9 M) [2]
p21 (RAC1) activated kinase 4 Hs Inhibitor Inhibition 8.0 pIC50 - 2
pIC50 8.0 (IC50 1x10-8 M) [2]
Description: Data from binding assays.
AKT serine/threonine kinase 2 Hs Inhibitor Inhibition 7.9 pIC50 - 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]
Protein kinase G (PKG) 1 Hs Inhibitor Inhibition 7.5 pIC50 - 2
pIC50 7.5 (IC50 3.3x10-8 M) [2]
p21 (RAC1) activated kinase 5 Hs Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 5.2x10-8 M) [2]