GSK690693

Ligand id: 5196

Name: GSK690693

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 137.14
Molecular weight 425.22
XLogP 1.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,4

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
AKT serine/threonine kinase 2 AKT2 Hs Inhibitor Inhibition 8.7 pKd
AKT serine/threonine kinase 1 AKT1 Hs Inhibitor Inhibition 8.7 pKd
protein kinase C eta PRKCH Hs Inhibitor Inhibition 8.6 pKd
AKT serine/threonine kinase 3 AKT3 Hs Inhibitor Inhibition 8.5 pKd
Protein kinase G (PKG) 2 PRKG2 Hs Inhibitor Inhibition 8.5 pKd
protein kinase C epsilon PRKCE Hs Inhibitor Inhibition 8.3 pKd
protein kinase X-linked PRKX Hs Inhibitor Inhibition 8.1 pKd
p21 (RAC1) activated kinase 5 PAK7 Hs Inhibitor Inhibition 8.1 pKd
protein kinase, cAMP-dependent, catalytic, beta subunit PKAC-beta Hs Inhibitor Inhibition 7.9 pKd
protein kinase C theta PRKCQ Hs Inhibitor Inhibition 7.8 pKd
Displaying the top 10 targets  View all targets in screen »