OL135   Click here for help

GtoPdb Ligand ID: 5235

Synonyms: OL-135 | ORL 135
Compound class: Synthetic organic
Comment: OL135 is an inhibitor of fatty acid amide hydrolase (FAAH) [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 55.99
Molecular weight 334.17
XLogP 4.51
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1ncc(o1)c1ccccn1)CCCCCCc1ccccc1
Isomeric SMILES O=C(c1ncc(o1)c1ccccn1)CCCCCCc1ccccc1
InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Fatty acid amide hydrolase-2 Hs Inhibitor Inhibition 7.9 – 8.4 pIC50 - 1-2
pIC50 7.9 – 8.4 (IC50 1.26x10-8 – 4x10-9 M) [1-2]
Fatty acid amide hydrolase Hs Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.98x10-8 M) [2]