OL135   Click here for help

GtoPdb Ligand ID: 5235

Synonyms: OL-135 | ORL 135
Compound class: Synthetic organic
Comment: OL135 is an inhibitor of fatty acid amide hydrolase (FAAH) [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 55.99
Molecular weight 334.17
XLogP 4.51
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1ncc(o1)c1ccccn1)CCCCCCc1ccccc1
Isomeric SMILES O=C(c1ncc(o1)c1ccccn1)CCCCCCc1ccccc1
InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
1. Karbarz MJ, Luo L, Chang L, Tham CS, Palmer JA, Wilson SJ, Wennerholm ML, Brown SM, Scott BP, Apodaca RL et al.. (2009)
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
Anesth Analg, 108 (1): 316-29. [PMID:19095868]
2. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006)
A second fatty acid amide hydrolase with variable distribution among placental mammals.
J Biol Chem, 281 (48): 36569-78. [PMID:17015445]