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Synonyms: OL-135 | ORL 135
Compound class: Synthetic organic
Comment: OL135 is an inhibitor of fatty acid amide hydrolase (FAAH) .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Karbarz MJ, Luo L, Chang L, Tham CS, Palmer JA, Wilson SJ, Wennerholm ML, Brown SM, Scott BP, Apodaca RL et al.. (2009)
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
Anesth Analg, 108 (1): 316-29. [PMID:19095868]
2. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006)
A second fatty acid amide hydrolase with variable distribution among placental mammals.
J Biol Chem, 281 (48): 36569-78. [PMID:17015445]