KF26777

Ligand id: 5618

Name: KF26777

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 67.97
Molecular weight 373.05
XLogP 4.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
A3 receptor Hs Antagonist Antagonist 9.7 pKi - 1
pKi 9.7 (Ki 2x10-10 M) [1]
A2A receptor Hs Antagonist Antagonist 6.3 pKi - 1
pKi 6.3 (Ki 4.7x10-7 M) [1]
A2B receptor Hs Antagonist Antagonist 6.2 pKi - 1
pKi 6.2 (Ki 6.2x10-7 M) [1]
A1 receptor Hs Antagonist Antagonist 5.7 pKi - 1
pKi 5.7 (Ki 1.8x10-6 M) [1]