tozasertib

Ligand id: 5718

Name: tozasertib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 127.37
Molecular weight 464.21
XLogP 3.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
aurora kinase A Hs Inhibitor Inhibition 8.4 pKd - 2
pKd 8.4 (Kd 3.9x10-9 M) [2]
aurora kinase A Hs Inhibitor Inhibition 9.2 pKi - 4
pKi 9.2 (Ki 6x10-10 M) [4]
aurora kinase C Hs Inhibitor Inhibition 8.3 pKi - 4
pKi 8.3 (Ki 4.6x10-9 M) [4]
aurora kinase B Hs Inhibitor Inhibition 7.7 pKi - 4
pKi 7.7 (Ki 1.8x10-8 M) [4]