AMG7703   Click here for help

GtoPdb Ligand ID: 5803

Synonyms: AMG 7703 | AMG-7703 | CFMB | phenylacetamide 1 [PMID: 18818303]
Compound class: Synthetic organic
Comment: This compound is a FFA2 receptor agonist [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 70.23
Molecular weight 294.06
XLogP 3.29
No. Lipinski's rules broken 0
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Canonical SMILES CC(C(C(=O)Nc1nccs1)c1ccc(cc1)Cl)C
Isomeric SMILES CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C
InChI InChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18)/t12-/m0/s1
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
FFA2 receptor Hs Allosteric modulator Positive 5.9 – 6.3 pEC50 - 1-2
pEC50 5.9 – 6.3 (EC50 1.27x10-6 – 4.5x10-7 M) [1-2]