AMG7703   Click here for help

GtoPdb Ligand ID: 5803

Synonyms: AMG 7703 | AMG-7703
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 70.23
Molecular weight 294.06
XLogP 3.29
No. Lipinski's rules broken 0
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Canonical SMILES CC(C(C(=O)Nc1nccs1)c1ccc(cc1)Cl)C
Isomeric SMILES CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C
InChI InChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18)/t12-/m0/s1
1. Lee T, Schwandner R, Swaminath G, Weiszmann J, Cardozo M, Greenberg J, Jaeckel P, Ge H, Wang Y, Jiao X et al.. (2008)
Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.
Mol Pharmacol, 74 (6): 1599-609. [PMID:18818303]
2. Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR et al.. (2011)
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.
Mol Pharmacol, 80 (1): 163-73. [PMID:21498659]