GSK-3 inhibitor IX

Ligand id: 5974

Name: GSK-3 inhibitor IX

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 73.72
Molecular weight 355
XLogP 3.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
The primary target for this compound is GSK3. The publicly available data use GSK3 (as a complex of α and β isozymes) isolated from pig brain [8].
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
glycogen synthase kinase 3 alpha Pig Inhibitor Inhibition 8.3 pIC50 - 6,8
pIC50 8.3 (IC50 5x10-9 M) [6,8]
Description: GSK3α/β complex from pig brain
glycogen synthase kinase 3 beta Pig Inhibitor Inhibition 8.3 pIC50 - 6,8
pIC50 8.3 (IC50 5x10-9 M) [6,8]
Description: GSK3α/β complex from pig brain
cyclin dependent kinase 5 Hs Inhibitor Inhibition 7.1 pIC50 - 6,8
pIC50 7.1 (IC50 8.3x10-8 M) [6,8]
Description: CDK5/p25 complex
cyclin dependent kinase 1 Hs Inhibitor Inhibition 6.5 pIC50 - 6,8
pIC50 6.5 (IC50 3.2x10-7 M) [6,8]
Description: CDK1/cyclin B complex