herbimycin A

Ligand id: 5984

Name: herbimycin A

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 152.48
Molecular weight 574.29
XLogP 0.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
Herbimycin A binds to reactive SH group(s) of cytoplasmic protein tyrosine kinases, thus inhibiting enzyme activity [2]. It has been demonstrated to inhibit BCR-ABL fusion protein, Hsp90 [5] and SRC