herbimycin A

Ligand id: 5984

Name: herbimycin A

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 152.48
Molecular weight 574.29
XLogP 0.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
mitogen-activated protein kinase kinase kinase 14 nd/NIK(MAP3K14) Hs Inhibitor Inhibition 67.9
interleukin 1 receptor associated kinase 1 IRAK1/IRAK1 Hs Inhibitor Inhibition 71.8 106.0 94.0
ribosomal protein S6 kinase A1 Rsk1/RSK1 Hs Inhibitor Inhibition 76.8 115.0 84.0
cyclin dependent kinase 1 CDK1-cyclin B/CDK1-cyclin B Hs Inhibitor Inhibition 77.5 111.0 110.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 79.6 68.0 72.0
serine/threonine-protein kinase MST4 nd/MSTR4 Hs Inhibitor Inhibition 85.3
casein kinase 1 epsilon nd/CK1epsilon Hs Inhibitor Inhibition 85.9
serine/threonine kinase 39 nd/STK39(STLK3) Hs Inhibitor Inhibition 86.5
protein kinase C zeta PKCζ/PKCzeta Hs Inhibitor Inhibition 86.8 104.0 106.0
EPH receptor B2 EphB2/EPHB2 Hs Inhibitor Inhibition 86.9 115.0 128.0
Displaying the top 10 targets  View all targets in screen »