ranatensin   Click here for help

GtoPdb Ligand ID: 618

Compound class: Peptide
Comment: Expressed by the skin glands of the northern leopard frog (Rana pipiens)
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES CSCCC(C(=O)N)NC(=O)C(NC(=O)C(Cc1[nH]cnc1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C1CCCN1C(=O)C(C(C)C)NC(=O)C1CCC(=O)N1)CCC(=O)N)C)Cc1ccccc1
Isomeric SMILES CSCCC(C(=O)N)NC(=O)C(NC(=O)C(Cc1[nH]cnc1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C1CCCN1C(=O)C(C(C)C)NC(=O)C1CCC(=O)N1)CCC(=O)N)C)Cc1ccccc1
InChI InChI=1S/C61H84N16O13S/c1-32(2)50(60(89)66-30-49(80)70-45(27-37-29-64-31-67-37)58(87)73-43(25-35-13-8-7-9-14-35)57(86)71-40(52(63)81)22-24-91-6)75-53(82)34(5)68-56(85)44(26-36-28-65-39-16-11-10-15-38(36)39)74-54(83)42(18-20-47(62)78)72-59(88)46-17-12-23-77(46)61(90)51(33(3)4)76-55(84)41-19-21-48(79)69-41/h7-11,13-16,28-29,31-34,40-46,50-51,65H,12,17-27,30H2,1-6H3,(H2,62,78)(H2,63,81)(H,64,67)(H,66,89)(H,68,85)(H,69,79)(H,70,80)(H,71,86)(H,72,88)(H,73,87)(H,74,83)(H,75,82)(H,76,84)
InChI Key AUOCWSNQHWTPIJ-UHFFFAOYSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
BB2 receptor Rn Agonist Full agonist 8.7 pKi - 1-2
pKi 8.7 (Ki 2x10-9 M) [1-2]
BB1 receptor Rn Agonist Full agonist 7.9 pKi - 1-2
pKi 7.9 (Ki 1.3x10-8 M) [1-2]
BB2 receptor Rn Agonist Full agonist 9.0 pIC50 - 3
pIC50 9.0 (IC50 1.08x10-9 M) [3]
BB1 receptor Hs Agonist Full agonist 8.4 – 8.8 pIC50 - 3
pIC50 8.4 – 8.8 (IC50 4.47x10-9 – 1.48x10-9 M) [3]
BB2 receptor Hs Agonist Full agonist 8.5 – 8.6 pIC50 - 3
pIC50 8.5 – 8.6 (IC50 3.16x10-9 – 2.24x10-9 M) [3]