ADX71743   Click here for help

GtoPdb Ligand ID: 6217

Synonyms: ADX 71743 | ADX-71743
Compound class: Synthetic organic
Comment: ADX71743 is a negative allosteric modulator (NAM) of mGlu7 [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 43.1
Molecular weight 269.14
XLogP 2.9
No. Lipinski's rules broken 0
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Canonical SMILES CCc1nc2c(o1)CC(CC2=O)c1ccc(cc1C)C
Isomeric SMILES CCc1nc2c(o1)CC(CC2=O)c1ccc(cc1C)C
InChI InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3
Bioactivity Comments
ADX71743 exhibits anxiolytic activity in vivo [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
mGlu7 receptor Hs Allosteric modulator Negative 7.2 pIC50 - 1
pIC50 7.2 (IC50 6.3x10-8 M) [1]
mGlu7 receptor Rn Allosteric modulator Negative 7.1 pIC50 - 1
pIC50 7.1 (IC50 8.8x10-8 M) [1]