MNI-135

Ligand id: 6219

Name: MNI-135

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 65.25
Molecular weight 401
XLogP 3.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
mGlu3 receptor Rn Allosteric modulator Negative 7.5 pEC50 - 1
pEC50 7.5 (EC50 3.02x10-8 M) [1]
mGlu2 receptor Rn Allosteric modulator Negative 7.5 – 7.7 pIC50 - 1
pIC50 7.5 – 7.7 (IC50 3.02x10-8 – 1.96x10-8 M) [1]
mGlu2 receptor Hs Allosteric modulator Negative 6.9 – 8.0 pIC50 - 1
pIC50 6.9 – 8.0 (IC50 1.18x10-7 – 1.05x10-8 M) [1]