efalizumab   Click here for help

GtoPdb Ligand ID: 6593

Synonyms: anti alphaL integrin | antiCD11 alpha | hu1124 | Raptiva®
Approved drug Immunopharmacology Ligand
efalizumab is an approved drug (FDA (2003), EMA (2004))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Bioactivity Comments
A peptide BLAST search using the heavy chain peptide sequence of efalizumab identifies sequence ID 5 in patent US6703018 [1] and data is presented from the monoclonal variant designated MHM24 F(ab)-8.
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Primary target of this compound Hs Antibody Binding 11.4 pKd - 1
pKd 11.4 (Kd 4x10-12 M) [1]
Description: Binding of humanized MHM24 to human CD11a on Jurkat cells.