efalizumab   Click here for help

GtoPdb Ligand ID: 6593

Synonyms: anti alphaL integrin | antiCD11 alpha | hu1124 | Raptiva®
Approved drug Immunopharmacology Ligand
efalizumab is an approved drug (FDA (2003), EMA (2004))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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No information available.
Summary of Clinical Use Click here for help
Used to treat psoriasis prior to withdrawl from the market.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The molecular target of this monoclonal antibody is ITGAL (integrin alpha L subunit, lymphocyte function associated antigen 1, aka CD11a). The antibody acts as an immunosuppressant by inhibiting lymphocyte activation and cell migration out of blood vessels into tissues.