Compound class:
Endogenous peptide in human, mouse or rat
Comment: The structure of mature human fibronectin varies according to the splice variants of the proteins cleaved from the precursor. Heteromeric, monomeric and homomeric variants exist. For more details, see the UniProt entry for this protein.
Species: Human
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Bioactivity Comments |
Rare genetic variants in FN1 appear to counteract the detrimental effects of the APOEε4 allele that is associated with Alzheimer's disease risk [1], likely by permitting better clearance of toxic amyloid out of the brain. |
Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Ligands at integrin α5β1 | fibronectin (FN1, P02751) | |
Ligands at integrin αIIbβ3 | fibrinogen (FGA, FGB, FGG, P02671, P02675, P02679), fibronectin (FN1, P02751), von Willebrand factor (VWF, P04275), vitronectin (VTN, P04004), thrombospondin | |
Ligands at integrin αVβ3 | vitronectin (VTN, P04004), fibronectin (FN1, P02751), fibrinogen (FGA, FGB, FGG, P02671, P02675, P02679), osteopontin (SPP1, P10451), von Willebrand factor (VWF, P04275), thrombospondin, tenascin | |
Ligands at integrin α4β1 | fibronectin (FN1, P02751), vascular cell adhesion protein 1 (VCAM1, P19320), osteopontin (SPP1, P10451), thrombospondin |
Ligand mentioned in the following text fields |
Integrins comments |