View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species
|AZD3839 inhibited Aβ and sAPPβ release from modified and wild-type human SH-SY5Y cells, mouse N2A cells, mouse and guinea pig primary cortical neurons. Selectivity against BACE2 and cathepsin D was 14 and >1000-fold, respectively. Dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and a non-human primate were demonstrated. Inhibited BACE1 activity in a biochemical fluorescence resonance energy transfer (FRET) assay.