anisindione   Click here for help

GtoPdb Ligand ID: 6960

Synonyms: Miradon®
Approved drug
anisindione is an approved drug (FDA (1957))
Compound class: Synthetic organic
Comment: Anisindione is a synthetic anticoagulant which inhibits vitamin K-dependent gamma-carboxylase.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 43.37
Molecular weight 252.08
XLogP 2.64
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc(cc1)C1C(=O)c2c(C1=O)cccc2
Isomeric SMILES COc1ccc(cc1)C1C(=O)c2c(C1=O)cccc2
InChI InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3
Bioactivity Comments
The majority of references for anisindione are very old and provide little in the way of molecular target validation. Although it is widely reported in various web and literature resources we have found no available, peer reviewed article to substantiate γ-glutamyl carboxylase as anisindione's primary molecular target .
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
γ-Glutamyl carboxylase Primary target of this compound Hs Inhibitor Inhibition - - -