romiplostim   Click here for help

GtoPdb Ligand ID: 6974

Synonyms: MG531 | Nplate®
Approved drug Immunopharmacology Ligand
romiplostim is an approved drug (FDA (2008), EMA (2009))
Comment: This drug is a thrombopoietin receptor agonist, although its peptide sequence does not resemble that of the endogenous peptide thrombopoietin. Romiplostim is known as a peptibody, a fusion between the Fc portion of immunoglobulin and a therapeutic peptide. In this case the drug exists as a heterodimer. The carboxy terminal 14 amino acid residues of this peptibody constitute the thrombopoietin receptor binding domain (single letter amino acid code: IEGPTLRQWLAARA).
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Thrombopoietin receptor Primary target of this compound Hs Agonist Agonist - - -