romiplostim   Click here for help

GtoPdb Ligand ID: 6974

Synonyms: MG531 | Nplate®
Approved drug Immunopharmacology Ligand
romiplostim is an approved drug (FDA (2008), EMA (2009))
Comment: This drug is a thrombopoietin receptor agonist, although its peptide sequence does not resemble that of the endogenous peptide thrombopoietin. Romiplostim is known as a peptibody, a fusion between the Fc portion of immunoglobulin and a therapeutic peptide. In this case the drug exists as a heterodimer. The carboxy terminal 14 amino acid residues of this peptibody constitute the thrombopoietin receptor binding domain (single letter amino acid code: IEGPTLRQWLAARA).
Immunopharmacology Comments
Increases the platelet count in ITP patients via activation of the thrombopoietin receptor to combat the autoimmune destruction of platelets in this disease.
Immunopharmacology Disease
Disease X-Refs Comment References
Autoimmune thrombocytopenic purpura Disease Ontology: DOID:8924
OMIM: 188030
Orphanet: ORPHA3002
Approved drug for autoimmune thrombocytopenic purpura (a.k.a. idiopathic thrombocytopenic purpura)