Lys-CoA   Click here for help

GtoPdb Ligand ID: 7036

Compound class: Synthetic organic
Comment: Lys-CoA, a histone acetyltransferase inhibitor, is a simple peptide-co-enzyme A conjugate. See Lau et al (2000) for structural details [2]. For a review of compounds being investigated as modulators of histone-modifying enzyme activity see [1].
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Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
lysine acetyltransferase 2B Hs Inhibitor Inhibition 3.7 pIC50 - 2
pIC50 3.7 (IC50 2x10-4 M) [2]
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
E1A binding protein p300 Hs Inhibitor Inhibition 6.3 pIC50 - 2
pIC50 6.3 (IC50 5x10-7 M) [2]