Lys-CoA   Click here for help

GtoPdb Ligand ID: 7036

Compound class: Synthetic organic
Comment: Lys-CoA, a histone acetyltransferase inhibitor, is a simple peptide-co-enzyme A conjugate. See Lau et al (2000) for structural details [2]. For a review of compounds being investigated as modulators of histone-modifying enzyme activity see [1].
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1. Cole PA. (2008)
Chemical probes for histone-modifying enzymes.
Nat Chem Biol, 4 (10): 590-7. [PMID:18800048]
2. Lau OD, Kundu TK, Soccio RE, Ait-Si-Ali S, Khalil EM, Vassilev A, Wolffe AP, Nakatani Y, Roeder RG, Cole PA. (2000)
HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.
Mol Cell, 5 (3): 589-95. [PMID:10882143]