linsitinib

Ligand id: 7423

Name: linsitinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 89.33
Molecular weight 421.19
XLogP 4.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Linsitinib is effective in vitro and in vivo, exhibiting antiproliferative activity in cell lines and in an IGF-1R-driven xenograft mouse model [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Insulin-like growth factor I receptor Hs Inhibitor Inhibition 7.5 pIC50 - 1
pIC50 7.5 (IC50 3.5x10-8 M) [1]
Description: Biochemical enzyme inhibition assay.
Insulin receptor Hs Inhibitor Inhibition 7.1 pIC50 - 1
pIC50 7.1 (IC50 7.5x10-8 M) [1]
Description: In a kinase screening selectivity assay.
Insulin receptor-related receptor Hs Inhibitor Inhibition 7.1 pIC50 - 1
pIC50 7.1 (IC50 7.5x10-8 M) [1]