linsitinib

Ligand id: 7423

Name: linsitinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 89.33
Molecular weight 421.19
XLogP 4.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Linsitinib is a drug candidate for the treatment of various types of cancer, with trials reaching Phase III. Visit ClinicalTrials.gov to view currently registered drug trials involving this compound.
Mechanism Of Action and Pharmacodynamic Effects
Linsitinib is a dual IGF-1R/insulin receptor (IR) kinase inhibitor. This inhibits IGF-1R-driven tumorigenesis and metastasis [1].