rufinamide   Click here for help

GtoPdb Ligand ID: 7470

Synonyms: Banzel® | CGP-33101 | Inovelon® | RUF-331
Approved drug
rufinamide is an approved drug (EMA (2007), FDA (2008))
Compound class: Synthetic organic
Comment: Rufinamide is a triazole (a heterocyclic compound with molecular formula C2H3N3) derivative anticonvulsant drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 73.8
Molecular weight 238.07
XLogP 0.89
No. Lipinski's rules broken 0
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Canonical SMILES Fc1cccc(c1Cn1nnc(c1)C(=O)N)F
Isomeric SMILES Fc1cccc(c1Cn1nnc(c1)C(=O)N)F
InChI InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
Bioactivity Comments
Rodent studies show that rufinamide (1μM) significantly slows sodium channel recovery from inactivation in cultured cortical neurons from immature rats and that the drug limits sustained repetitive firing of sodium-dependent action potentials, with an EC50 of 3.8μM [1].
However, we have been unable to find publicly available bioactivity data for this drug at its proposed human molecular target(s) to substantiate its MMOA, and have therefore not tagged a primary drug target.