rufinamide   Click here for help

GtoPdb Ligand ID: 7470

Synonyms: Banzel® | CGP-33101 | Inovelon® | RUF-331
Approved drug
rufinamide is an approved drug (EMA (2007), FDA (2008))
Compound class: Synthetic organic
Comment: Rufinamide is a triazole (a heterocyclic compound with molecular formula C2H3N3) derivative anticonvulsant drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 73.8
Molecular weight 238.07
XLogP 0.89
No. Lipinski's rules broken 0
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Canonical SMILES Fc1cccc(c1Cn1nnc(c1)C(=O)N)F
Isomeric SMILES Fc1cccc(c1Cn1nnc(c1)C(=O)N)F
InChI InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
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Summary of Clinical Use Click here for help
Rufinamide is used in combination with other medications to treat adults and children suffering epileptic seizures caused by Lennox-Gastaut syndrome. As of February 2015, approval was extended for this indication to include treatment of children from one year old, where previously only children >4 years could be treated with this drug.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
By blocking sodium channel alpha subunits, rufinamide prolongs the time that the channels remain in the inactive state. This stabilises the neuronal membranes and ultimately prevents the spread of seizure activity from an epileptogenic focus.
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