Synonyms: ASP 3026 | ASP3026
Compound class:
Synthetic organic
Comment: ASP-3026 is a second generation ALK inhibitor designed to target ALK rearrangements which are the oncogenic drivers of some non-small cell lung cancers (NSCLCs) and T-cell lymphomas known as ALK- expressing anaplastic large-cell lymphoma (ALK+ALCL) .
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Bioactivity Comments |
ASP-3026 is effective against NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in vivo [1]. It also effective against tumour cells expressing the EML4-ALK rearrangement, even when possessing a crizotinib-resistance-conferring gatekeeper mutation (L1196M) [2] (in vivo and in vitro results). We have been unable to find affinity data for ASP-3026 using recombinant ALK protein. |